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Non-coding mutations drive persistence of a founder pre-leukemic clone which initiates late relapse in T-ALL

T-ALL relapse usually occurs early but can occur much later, which has been suggested to represent a de novo leukemia. However, we conclusively demonstrate late relapse can evolve from a pre-leukemic subclone harbouring a non-coding mutation that evades initial chemotherapy. Data include 19 WGS samples: - 5 cases with presentation, relapse and remission (germline) samples - 2 cases with presentation and relapse samples, but not remission (germline)

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000129 Cancer Genomics
  • Publication id added to the study
  • Dataset Released

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000061895 bam 95.3 GB
EGAF50000061896 bam 56.2 GB
EGAF50000061897 bam 94.2 GB
EGAF50000061898 bam 91.8 GB
EGAF50000061899 bam 56.3 GB
EGAF50000061900 bam 95.9 GB
EGAF50000061901 bam 100.6 GB
EGAF50000061902 bam 91.1 GB
EGAF50000061903 bam 67.3 GB
EGAF50000061904 bam 86.4 GB
EGAF50000061905 bam 105.6 GB
EGAF50000061906 bam 58.5 GB
EGAF50000061907 bam 97.5 GB
EGAF50000061908 bam 100.7 GB
EGAF50000061909 bam 95.4 GB
EGAF50000061910 bam 64.5 GB
EGAF50000061911 bam 102.7 GB
EGAF50000061912 bam 112.9 GB
EGAF50000061913 bam 95.0 GB
19 Files (1.7 TB)