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Longitudinal Single-Cell Profiling in Refractory Mantle Cell Lymphoma

we performed sequential scRNA-seq of 21 specimens (discovery cohort) collected at baseline, during treatment, and/or at disease remission/progression from 3 ibrutinib-responsive (R) patients (Pt-V, C and D) and 2 non-responsive (NR) patients (Pt-B and E). In addition, the PBMC samples from two healthy donors (N1 and N2) were included as the normal controls.

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The Wang Laboratory research program aims to elucidate the mechanisms underlying therapeutic resistance in B-cell lymphoma and to translate these findings to the clinic to improve patient outcomes. The research group has utilized genomics and molecular analysis, patient-derived xenograft (PDX) mouse models and state-of-the-art molecular tools to understand the cellular mechanisms responsible for therapeutic resistance and disease progression in mantle cell lymphoma (MCL), with rapid expansion into diffuse large B-cell lymphoma (DLBCL).

For each dataset that requires controlled access, there is a corresponding Data Access Committee (DAC) who determine access permissions. Access to actual data files is not managed by the EGA. If you need to request access to this data set, please contact

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001005019 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF00004996313 bam 9.4 GB Report
EGAF00004996314 bam 11.0 GB Report
EGAF00004996315 bam 10.2 GB Report
EGAF00004996316 bam 10.3 GB Report
EGAF00004996317 fastq.gz 362.1 MB Report
EGAF00004996318 fastq.gz 1.3 GB Report
EGAF00004996319 fastq.gz 402.1 MB Report
EGAF00004996320 fastq.gz 1.4 GB Report
EGAF00004996321 fastq.gz 402.1 MB Report
EGAF00004996322 fastq.gz 1.4 GB Report
EGAF00004996323 fastq.gz 563.8 MB Report
EGAF00004996324 fastq.gz 2.1 GB Report
EGAF00004996331 fastq.gz 510.0 MB Report
EGAF00004996332 fastq.gz 1.8 GB Report
EGAF00004996333 fastq.gz 564.4 MB Report
EGAF00004996334 fastq.gz 2.0 GB Report
EGAF00004996335 fastq.gz 566.7 MB Report
EGAF00004996336 fastq.gz 2.0 GB Report
EGAF00004996337 fastq.gz 487.3 MB Report
EGAF00004996338 fastq.gz 1.8 GB Report
EGAF00004996339 fastq.gz 625.7 MB Report
EGAF00004996340 fastq.gz 2.3 GB Report
EGAF00004996341 fastq.gz 624.1 MB Report
EGAF00004996342 fastq.gz 2.3 GB Report
EGAF00004996343 fastq.gz 558.1 MB Report
EGAF00004996344 fastq.gz 2.0 GB Report
EGAF00004996345 fastq.gz 542.0 MB Report
EGAF00004996346 fastq.gz 2.0 GB Report
EGAF00004996347 fastq.gz 553.5 MB Report
EGAF00004996348 fastq.gz 2.0 GB Report
EGAF00004996349 fastq.gz 472.5 MB Report
EGAF00004996350 fastq.gz 1.8 GB Report
EGAF00004996351 fastq.gz 525.6 MB Report
EGAF00004996352 fastq.gz 1.9 GB Report
EGAF00004996353 fastq.gz 2.7 GB Report
EGAF00004996354 fastq.gz 12.5 GB Report
EGAF00004996355 fastq.gz 537.4 MB Report
EGAF00004996356 fastq.gz 2.0 GB Report
EGAF00004996357 fastq.gz 2.5 GB Report
EGAF00004996358 fastq.gz 11.9 GB Report
EGAF00004996359 fastq.gz 827.9 MB Report
EGAF00004996360 fastq.gz 3.1 GB Report
EGAF00004996361 fastq.gz 945.2 MB Report
EGAF00004996362 fastq.gz 3.6 GB Report
EGAF00004996363 fastq.gz 921.9 MB Report
EGAF00004996364 fastq.gz 3.5 GB Report
EGAF00004996365 fastq.gz 938.5 MB Report
EGAF00004996366 fastq.gz 3.5 GB Report
EGAF00004996367 fastq.gz 526.0 MB Report
EGAF00004996368 fastq.gz 1.9 GB Report
EGAF00004996369 fastq.gz 602.6 MB Report
EGAF00004996370 fastq.gz 2.2 GB Report
EGAF00004996371 fastq.gz 586.7 MB Report
EGAF00004996372 fastq.gz 2.2 GB Report
EGAF00004996373 fastq.gz 598.5 MB Report
EGAF00004996374 fastq.gz 2.2 GB Report
EGAF00004996375 fastq.gz 2.5 GB Report
EGAF00004996376 fastq.gz 11.6 GB Report
EGAF00004996377 fastq.gz 558.4 MB Report
EGAF00004996378 fastq.gz 2.0 GB Report
EGAF00004996379 fastq.gz 621.7 MB Report
EGAF00004996380 fastq.gz 2.2 GB Report
EGAF00004996381 fastq.gz 584.7 MB Report
EGAF00004996382 fastq.gz 2.1 GB Report
EGAF00004996383 fastq.gz 587.4 MB Report
EGAF00004996384 fastq.gz 2.5 GB Report
EGAF00004996385 fastq.gz 604.8 MB Report
EGAF00004996386 fastq.gz 2.6 GB Report
EGAF00004996387 fastq.gz 592.7 MB Report
EGAF00004996388 fastq.gz 2.5 GB Report
EGAF00004996389 fastq.gz 655.9 MB Report
EGAF00004996390 fastq.gz 2.6 GB Report
EGAF00004996391 fastq.gz 537.6 MB Report
EGAF00004996392 fastq.gz 2.3 GB Report
EGAF00004996393 fastq.gz 553.5 MB Report
EGAF00004996394 fastq.gz 2.3 GB Report
EGAF00004996395 fastq.gz 542.5 MB Report
EGAF00004996396 fastq.gz 2.3 GB Report
EGAF00004996397 fastq.gz 600.2 MB Report
EGAF00004996398 fastq.gz 2.4 GB Report
EGAF00004996399 fastq.gz 590.5 MB Report
EGAF00004996400 fastq.gz 2.5 GB Report
EGAF00004996401 fastq.gz 657.9 MB Report
EGAF00004996402 fastq.gz 2.6 GB Report
EGAF00004996403 fastq.gz 595.5 MB Report
EGAF00004996404 fastq.gz 2.5 GB Report
EGAF00004996405 fastq.gz 598.7 MB Report
EGAF00004996406 fastq.gz 2.5 GB Report
EGAF00004996407 fastq.gz 833.4 MB Report
EGAF00004996517 fastq.gz 621.0 MB Report
EGAF00004996518 fastq.gz 2.2 GB Report
EGAF00004996519 fastq.gz 630.0 MB Report
EGAF00004996520 fastq.gz 2.2 GB Report
EGAF00004996521 fastq.gz 659.2 MB Report
EGAF00004996522 fastq.gz 2.3 GB Report
EGAF00004996523 fastq.gz 651.5 MB Report
EGAF00004996524 fastq.gz 2.3 GB Report
EGAF00004996525 fastq.gz 651.0 MB Report
EGAF00004996526 fastq.gz 2.3 GB Report
EGAF00004996527 fastq.gz 607.4 MB Report
EGAF00004996528 fastq.gz 2.6 GB Report
EGAF00004996529 fastq.gz 2.6 GB Report
EGAF00004996530 fastq.gz 12.6 GB Report
EGAF00004996531 fastq.gz 2.5 GB Report
EGAF00004996532 fastq.gz 11.8 GB Report
EGAF00004996533 fastq.gz 586.3 MB Report
EGAF00004996534 fastq.gz 2.2 GB Report
EGAF00004996535 fastq.gz 585.2 MB Report
EGAF00004996536 fastq.gz 2.2 GB Report
EGAF00004996606 fastq.gz 514.3 MB Report
EGAF00004996607 fastq.gz 1.9 GB Report
EGAF00004996608 fastq.gz 585.5 MB Report
EGAF00004996609 fastq.gz 2.2 GB Report
EGAF00004996610 fastq.gz 515.4 MB Report
EGAF00004996611 fastq.gz 1.9 GB Report
EGAF00004996612 fastq.gz 609.3 MB Report
EGAF00004996613 fastq.gz 2.2 GB Report
EGAF00004996614 fastq.gz 533.2 MB Report
EGAF00004996615 fastq.gz 1.9 GB Report
EGAF00004996616 fastq.gz 663.0 MB Report
EGAF00004996617 fastq.gz 2.4 GB Report
EGAF00004996618 fastq.gz 657.6 MB Report
EGAF00004996619 fastq.gz 2.4 GB Report
EGAF00004996620 fastq.gz 662.1 MB Report
EGAF00004996621 fastq.gz 2.4 GB Report
EGAF00004996622 fastq.gz 580.2 MB Report
EGAF00004996623 fastq.gz 2.1 GB Report
EGAF00004996624 fastq.gz 2.6 GB Report
EGAF00004996625 fastq.gz 12.8 GB Report
EGAF00004996626 fastq.gz 573.3 MB Report
EGAF00004996627 fastq.gz 2.0 GB Report
EGAF00004996628 fastq.gz 541.2 MB Report
EGAF00004996629 fastq.gz 2.0 GB Report
EGAF00004996630 fastq.gz 634.0 MB Report
EGAF00004996631 fastq.gz 2.3 GB Report
EGAF00004996632 fastq.gz 406.8 MB Report
EGAF00004996633 fastq.gz 1.4 GB Report
EGAF00005028363 fastq.gz 16.4 GB Report
EGAF00005028364 fastq.gz 16.8 GB Report
EGAF00005029055 fastq.gz 15.4 GB Report
EGAF00005029056 fastq.gz 15.9 GB Report
EGAF00005029061 fastq.gz 15.0 GB Report
EGAF00005029062 fastq.gz 15.4 GB Report
EGAF00005029063 fastq.gz 14.9 GB Report
EGAF00005029064 fastq.gz 15.3 GB Report
EGAF00005029209 fastq.gz 15.7 GB Report
EGAF00005029210 fastq.gz 16.2 GB Report
EGAF00005029223 fastq.gz 16.3 GB Report
EGAF00005029224 fastq.gz 16.7 GB Report
EGAF00005029225 fastq.gz 16.0 GB Report
EGAF00005029226 fastq.gz 16.4 GB Report
EGAF00005029227 fastq.gz 14.8 GB Report
EGAF00005029228 fastq.gz 15.4 GB Report
153 Files (552.4 GB)