Genomic and transcriptomic profiling of leiomyosarcoma

DATA ACCESS AGREEMENT These terms and conditions govern access to and processing of the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions and any appendices or addenda hereto, which are hereby incorporated (collectively, the “Agreement”). Definitions Authorised Personnel: The individuals at the User Institution to whom Beth Israel Deaconess Medical Center grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: Beth Israel Deaconess Medical Center and the collaborators listed in Appendix I responsible for the development, organization, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. BIDMC Proteogenomics Data Access Committee: means the access committee consisting of member(s) from BIDMC, as designated by BIDMC, from time to time (and any other members added in BIDMC’s discretion) to govern and decide whether to approve access to the Data for a particular Project. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The institution that has requested access to the Data and any of its Authorised Personnel. BIDMC: Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognizing the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analyzing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify BIDMC within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify BIDMC prior to any significant changes to the protocol for the Project. 14. The User Institution will notify BIDMC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. BIDMC may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of the United States and shall be subject to the exclusive jurisdiction of the United States courts. [Signatures to follow] Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for BIDMC Proteogenomics Data Access Committee: Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II – PROJECT DETAILS APPENDIX III – PUBLICATION POLICY APPENDIX I – DATA DETAILS Dataset reference (EGA Study ID and Dataset Details): The Data are comprised of sequencing data (patients and controls), process metrics, and de-identified clinical data. These Data were used to produce the results presented in the paper. Names of initial members of the BIDMC Proteogenomics Data Access Committee: Atsushi Tanaka, MD, PhD (atanaka@bidmc.harvard.edu; BIDMC, Boston, MA) Michael Roehrl, MD, PhD (michael_roehrl@bidmc.harvard.edu; BIDMC, Boston, MA) Specific limitations on areas of research: BIDMC Proteogenomics Data Access Committee may specify additional limitations on areas of research with respect to the Data from time to time. User Institution will be informed of any such limitations and the User Institution may elect to accept the limitations or agree to termination of the Agreement. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of Data requested i.e., EGA Study and Dataset Accession Number: Brief abstract of the Project in which the Data will be used (500 words max): All Individuals who the User Institution to be named as registered users: Name of Registered User Email Job Title Supervisor All Individuals that should have an account created at the EGA: Name of Registered User Email Job Title APPENDIX III – PUBLICATION POLICY BIDMC intend to publish the results of their analysis of these Data and do not consider the deposition of these Data into public databases to be the equivalent of such publications. BIDMC anticipate that the Data could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium, as follows: The publication moratorium covers and neither User Institution nor any User shall make any disclosures or publications (including poster and oral communications) that describe the use of the Data or results of the Project. For research papers or poster/oral communications, submission for publication or presentation by User Institution and/or User shall not occur until eighteen (18) months after these Data and analyses therefrom are first made public in manuscript by BIDMC, unless the BIDMC Proteogenomics Data Access Committee has provided express written consent to earlier submission. Any publications based on these Data must describe how the Data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers, and acknowledge the use of such Data in a form submitted by the User Institution for the BIDMC Proteogenomics Data Access Committee review and approval prior to publication.