About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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Hematological toxicity following CAR-T cells injection dataset

This dataset containes 44 paired of bulk RNA sequencing and 42 parired of single cell RNA sequencing issued from bone marrow aspirations obtained from patients treated with CAR-T (CD3+, CAR T+, CD34+ sorted populations).

Request Access

Policy for Hematological toxicity following CAR-T cells injection

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorized Personnel: The individuals at the User Institution to whom the Data Access Committee grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorized Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The individuals, listed in Appendix I, responsible for the development, organization, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution(s) that has requested access to the Data (detailed in Appendix II). Data Producers Institution(s): The Institution(s) that has produced the Data (detailed in Appendix I). Data Access Committee: The committee responsible for authorizing access to the data. Committee members are listed in Appendix I. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorized Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (https://www.sanger.ac.uk/wp-content/uploads/fortlauderdalereport.pdf) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognizing the contribution of the Data Producers and including a proper acknowledgment in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analyzing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.ott.nih.gov/sites/default/files/documents/pdfs/70fr18413.pdf) in conformity with the Organization for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (https://www.oecd.org/sti/emerging-tech/36198812.pdf). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the Data Access Committee within 30 days of any changes or departures of Authorized Personnel. 13. The User Institution will notify the Data Access Committee prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the Data Access Committee as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The Data Access Committee may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorized Personnel. The User Institution will procure that the Authorized Personnel comply with the terms of this agreement. 19.This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of France and shall be subject to the exclusive jurisdiction of the France courts. Agreed for User Institution (Name, Title, Date, Signature): Principal Investigator (Name, Title, Date, Signature): I confirm that I have read and understood this Agreement. Agreed for the Data Access Committee (Name, Title, Date, Signature): APPENDIX I – DATASET DETAILS & DATA ACCESS COMMITTEE APPENDIX II – PROJECT DETAILS APPENDIX III – PUBLICATION POLICY APPENDIX I – DATASET DETAILS & DATA ACCESS COMMITTEE Dataset reference (EGA Study ID, Dataset Accession Numbers and Dataset Details): Name of the project that created the dataset : Hematological toxicity following CAR-T cells injection Data Producers Institution(s): Gustave Roussy, 114, rue Edouard Vaillant – 94805 VILLEJUIF Cedex, FRANCE Names of other data producers/collaborators (Name, Email, Job Title): Specific limitations on areas of research: File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. Name of the Data Access Committee: Data Access Committee Members (Name, Email, Job Title): Principal Investigator Janesa SRIKANTHAN (Janesa.SRIKANTHAN@gustaveroussy.fr) CAMILLE BIGENWALD (CAMILLE.BIGENWALD@gustaveroussy.fr) Myriam BEN-KHELIL (Myriam.BEN-KHELIL@gustaveroussy.fr) Head of Bioinformatics platform Marc Deloger (Marc.DELOGER@gustaveroussy.fr) Bio-informatician Marine AGLAVE (Marine.AGLAVE@gustaveroussy.fr) Remy JELIN (Remy.JELIN@gustaveroussy.fr) Data Manager Alicia Tran Dien (Alicia.TRAN-DIEN@gustaveroussy.fr) Data Protection Officer Clara BECHET (Clara.BECHET@gustaveroussy.fr) APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of dataset requested i.e., EGA Study and Dataset Accession Number: Brief abstract of the Project in which the Data will be used (500 words max): User Institution(s): All Individuals who the User Institution to be named as registered users (Name, Email, Job Title, Supervisor): All Individuals that should have an account created at the EGA (Name, Email, Job Title): APPENDIX III – PUBLICATION POLICY The Data Access Committee anticipates that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until the Data Access Committee have published their own global analysis or twelve (12) months after these data were first made available on the relevant hosting database, unless the Data Access Committee has provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the User Institution with the Data Access Committee.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000776 RNASeq
EGAS50000000777 RNASeq

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF50000276173 fastq.gz 440.0 MB
EGAF50000276174 fastq.gz 466.7 MB
EGAF50000276175 fastq.gz 8.6 GB
EGAF50000276176 fastq.gz 9.3 GB
EGAF50000276177 fastq.gz 183.7 MB
EGAF50000276178 fastq.gz 201.0 MB
EGAF50000276179 fastq.gz 2.4 GB
EGAF50000276180 fastq.gz 2.7 GB
EGAF50000276181 fastq.gz 6.1 GB
EGAF50000276182 fastq.gz 6.8 GB
EGAF50000276183 fastq.gz 1.7 MB
EGAF50000276184 fastq.gz 1.8 MB
EGAF50000276185 fastq.gz 486.6 MB
EGAF50000276186 fastq.gz 456.2 MB
EGAF50000276187 fastq.gz 3.1 GB
EGAF50000276188 fastq.gz 2.8 GB
EGAF50000276189 fastq.gz 20.6 GB
EGAF50000276190 fastq.gz 22.9 GB
EGAF50000276191 fastq.gz 13.5 GB
EGAF50000276192 fastq.gz 14.9 GB
EGAF50000276193 fastq.gz 5.5 GB
EGAF50000276194 fastq.gz 5.9 GB
EGAF50000276195 fastq.gz 293.0 MB
EGAF50000276196 fastq.gz 314.3 MB
EGAF50000276197 fastq.gz 3.8 GB
EGAF50000276198 fastq.gz 4.2 GB
EGAF50000276199 fastq.gz 617.6 MB
EGAF50000276200 fastq.gz 657.2 MB
EGAF50000276201 fastq.gz 4.4 GB
EGAF50000276202 fastq.gz 4.9 GB
EGAF50000276203 fastq.gz 2.3 GB
EGAF50000276204 fastq.gz 1.0 GB
EGAF50000276205 fastq.gz 2.2 GB
EGAF50000276206 fastq.gz 981.5 MB
EGAF50000276207 fastq.gz 1.1 GB
EGAF50000276208 fastq.gz 1.2 GB
EGAF50000276209 fastq.gz 2.3 GB
EGAF50000276210 fastq.gz 2.5 GB
EGAF50000276211 fastq.gz 5.2 GB
EGAF50000276212 fastq.gz 5.7 GB
EGAF50000276213 fastq.gz 3.7 GB
EGAF50000276214 fastq.gz 4.0 GB
EGAF50000276215 fastq.gz 2.6 GB
EGAF50000276216 fastq.gz 2.3 GB
EGAF50000276217 fastq.gz 5.2 GB
EGAF50000276218 fastq.gz 6.0 GB
EGAF50000276219 fastq.gz 1.6 GB
EGAF50000276220 fastq.gz 1.8 GB
EGAF50000276221 fastq.gz 4.5 GB
EGAF50000276222 fastq.gz 5.1 GB
EGAF50000276223 fastq.gz 867.5 MB
EGAF50000276224 fastq.gz 956.3 MB
EGAF50000276225 fastq.gz 2.2 GB
EGAF50000276226 fastq.gz 2.4 GB
EGAF50000276227 fastq.gz 160.6 MB
EGAF50000276228 fastq.gz 173.9 MB
EGAF50000276229 fastq.gz 750.1 MB
EGAF50000276230 fastq.gz 673.6 MB
EGAF50000276231 fastq.gz 343.8 MB
EGAF50000276232 fastq.gz 369.3 MB
EGAF50000276233 fastq.gz 1.9 GB
EGAF50000276234 fastq.gz 1.7 GB
EGAF50000276235 fastq.gz 28.2 GB
EGAF50000276236 fastq.gz 25.1 GB
EGAF50000276237 fastq.gz 2.6 GB
EGAF50000276238 fastq.gz 3.0 GB
EGAF50000276239 fastq.gz 1.7 GB
EGAF50000276240 fastq.gz 1.9 GB
EGAF50000276241 fastq.gz 177.4 MB
EGAF50000276242 fastq.gz 193.5 MB
EGAF50000276243 fastq.gz 6.1 GB
EGAF50000276244 fastq.gz 5.5 GB
EGAF50000276245 fastq.gz 27.0 GB
EGAF50000276246 fastq.gz 29.3 GB
EGAF50000276247 fastq.gz 1.2 GB
EGAF50000276248 fastq.gz 1.3 GB
EGAF50000276249 fastq.gz 832.5 MB
EGAF50000276250 fastq.gz 934.0 MB
EGAF50000276251 fastq.gz 628.7 MB
EGAF50000276252 fastq.gz 686.8 MB
EGAF50000276253 fastq.gz 2.8 GB
EGAF50000276254 fastq.gz 3.1 GB
EGAF50000276255 fastq.gz 4.6 GB
EGAF50000276256 fastq.gz 4.2 GB
EGAF50000276257 fastq.gz 2.9 GB
EGAF50000276258 fastq.gz 3.2 GB
EGAF50000276259 fastq.gz 2.8 GB
EGAF50000276260 fastq.gz 2.6 GB
EGAF50000276261 fastq.gz 861.6 MB
EGAF50000276262 fastq.gz 941.7 MB
EGAF50000276263 fastq.gz 910.9 MB
EGAF50000276264 fastq.gz 983.8 MB
EGAF50000276265 fastq.gz 612.9 MB
EGAF50000276266 fastq.gz 1.4 GB
EGAF50000276267 fastq.gz 1.2 GB
EGAF50000276268 fastq.gz 2.7 GB
EGAF50000276269 fastq.gz 596.2 MB
EGAF50000276270 fastq.gz 1.4 GB
EGAF50000276271 fastq.gz 2.6 GB
EGAF50000276272 fastq.gz 1.1 GB
EGAF50000276273 fastq.gz 2.0 GB
EGAF50000276274 fastq.gz 947.6 MB
EGAF50000276275 fastq.gz 922.4 MB
EGAF50000276276 fastq.gz 2.0 GB
EGAF50000276277 fastq.gz 525.9 MB
EGAF50000276278 fastq.gz 1.1 GB
EGAF50000276279 fastq.gz 521.7 MB
EGAF50000276280 fastq.gz 1.1 GB
EGAF50000276281 fastq.gz 957.3 MB
EGAF50000276282 fastq.gz 2.2 GB
EGAF50000276283 fastq.gz 652.2 MB
EGAF50000276284 fastq.gz 1.5 GB
EGAF50000276285 fastq.gz 928.1 MB
EGAF50000276286 fastq.gz 2.1 GB
EGAF50000276287 fastq.gz 639.1 MB
EGAF50000276288 fastq.gz 1.5 GB
EGAF50000276289 fastq.gz 858.1 MB
EGAF50000276290 fastq.gz 2.0 GB
EGAF50000276291 fastq.gz 833.0 MB
EGAF50000276292 fastq.gz 1.9 GB
EGAF50000276293 fastq.gz 204.1 MB
EGAF50000276294 fastq.gz 473.2 MB
EGAF50000276295 fastq.gz 198.8 MB
EGAF50000276296 fastq.gz 459.5 MB
EGAF50000276297 fastq.gz 1.2 GB
EGAF50000276298 fastq.gz 2.1 GB
EGAF50000276299 fastq.gz 1.2 GB
EGAF50000276300 fastq.gz 2.1 GB
EGAF50000276301 fastq.gz 795.5 MB
EGAF50000276302 fastq.gz 1.6 GB
EGAF50000276303 fastq.gz 767.8 MB
EGAF50000276304 fastq.gz 1.6 GB
EGAF50000276305 fastq.gz 770.0 MB
EGAF50000276306 fastq.gz 1.6 GB
EGAF50000276307 fastq.gz 1.6 GB
EGAF50000276308 fastq.gz 747.3 MB
EGAF50000276309 fastq.gz 672.9 MB
EGAF50000276310 fastq.gz 290.5 MB
EGAF50000276311 fastq.gz 661.6 MB
EGAF50000276312 fastq.gz 286.3 MB
EGAF50000276313 fastq.gz 691.8 MB
EGAF50000276314 fastq.gz 304.5 MB
EGAF50000276315 fastq.gz 296.2 MB
EGAF50000276316 fastq.gz 672.6 MB
EGAF50000276317 fastq.gz 1.7 GB
EGAF50000276318 fastq.gz 3.5 GB
EGAF50000276319 fastq.gz 1.6 GB
EGAF50000276320 fastq.gz 3.4 GB
EGAF50000276321 fastq.gz 1.5 GB
EGAF50000276322 fastq.gz 3.2 GB
EGAF50000276323 fastq.gz 1.5 GB
EGAF50000276324 fastq.gz 3.2 GB
EGAF50000276325 fastq.gz 271.9 MB
EGAF50000276326 fastq.gz 578.9 MB
EGAF50000276327 fastq.gz 270.0 MB
EGAF50000276328 fastq.gz 573.1 MB
EGAF50000276329 fastq.gz 556.7 MB
EGAF50000276330 fastq.gz 1.3 GB
EGAF50000276331 fastq.gz 537.4 MB
EGAF50000276332 fastq.gz 1.2 GB
EGAF50000276333 fastq.gz 257.6 MB
EGAF50000276334 fastq.gz 597.3 MB
EGAF50000276335 fastq.gz 249.3 MB
EGAF50000276336 fastq.gz 577.6 MB
EGAF50000276337 fastq.gz 2.4 GB
EGAF50000276338 fastq.gz 1.1 GB
EGAF50000276339 fastq.gz 1.1 GB
EGAF50000276340 fastq.gz 2.3 GB
EGAF50000276341 fastq.gz 454.3 MB
EGAF50000276342 fastq.gz 1.0 GB
EGAF50000276343 fastq.gz 446.0 MB
EGAF50000276344 fastq.gz 1.0 GB
172 Files (480.7 GB)