Single-nucleus RNA-sequencing data of kidney biopsies from patients with primary FSGS, maladaptive FSGS, proteinuric controls and healthy controls
This dataset includes FASTQ files of single-nucleus RNA sequencing of cryopreserved kidney biopsy cores from adult patients with diagnosed primary FSGS (n = 9, all nephrotic), maladaptive FSGS (n = 9, not nephrotic), proteinuric controls (PLA2R-positive membranous nephropathy, n = 3), and healthy controls (n = 4). A total of 120,751 high-quality nuclei were identified, including 2,471 podocytes and 1,574 parietal epithelial cells (PECs). In addition to the raw FASTQ files, the dataset includes processed data files from all 25 samples, generated using Seurat in R: barcode files, features, count matrices, and associated metadata. Details regarding the bioinformatics pipeline can be found at https://github.com/lambrechtslab/FSGS_Deleersnijder_et_al
- 01/09/2025
- 26 samples
- DAC: EGAC00001002157
- Technology: Illumina NovaSeq 6000
VIB Policy for Data Access and Data Transfer
VIB Policy for Data Access and Data Transfer Applicability This policy applies to the access to and transfer of VIB research datasets that contain non-anonymous Personal Data which are subject to the provisions of the General Data Protection Regulation (EU) 2016/679. Access/transfer conditions - The access/transfer is subject to approval by the VIB Data Access Committee. - The proposed research purpose should not be incompatible with the primary research purpose for which the data were originally generated. - The Recipient shall have in place adequate safeguards for the protection of Personal Data. - Access is subject to a Data Transfer/Access Agreement which will be managed by VIB Innovation & Business. - The Data Transfer/Access will be limited to the Data that are necessary for the proposed research. Access/transfer procedure - Requests to access or obtain non-anonymous datasets should be submitted to the responsible corresponding author that has uploaded the dataset into the repository, and with a copy to dac@vib.be. - The request should contain the following information: o Name, affiliation (legal entity) and contact information of the requesting recipient party. o Reference to the specific dataset(s) for which access or transfer is requested. o Description of the research purpose for which the data will be used. - The VIB Data Access Committee takes decisions to approve access/transfer within 14 days upon receipt of the request. - Data access will be given / Data will be transferred after completion of the Data Transfer/Access Agreement.
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS50000001070 | RNASeq |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
Located in
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| EGAF50000384175 | fastq.gz | 8.7 GB |
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| EGAF50000384176 | fastq.gz | 14.9 GB |
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| EGAF50000384177 | fastq.gz | 11.5 GB |
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| EGAF50000384178 | fastq.gz | 19.0 GB |
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| EGAF50000384179 | fastq.gz | 7.7 GB |
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| EGAF50000384180 | fastq.gz | 11.4 GB |
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| EGAF50000384181 | fastq.gz | 8.3 GB |
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| EGAF50000384182 | fastq.gz | 17.3 GB |
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| EGAF50000384183 | fastq.gz | 5.3 GB |
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| EGAF50000384184 | fastq.gz | 10.5 GB |
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| EGAF50000384185 | fastq.gz | 7.6 GB |
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| EGAF50000384186 | fastq.gz | 16.5 GB |
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| EGAF50000384187 | fastq.gz | 11.3 GB |
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| EGAF50000384188 | fastq.gz | 24.0 GB |
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| EGAF50000384189 | fastq.gz | 4.9 GB |
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| EGAF50000384190 | fastq.gz | 10.2 GB |
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| EGAF50000384191 | fastq.gz | 5.6 GB |
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| EGAF50000384192 | fastq.gz | 11.3 GB |
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| EGAF50000384193 | fastq.gz | 5.7 GB |
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| EGAF50000384194 | fastq.gz | 11.9 GB |
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| EGAF50000384195 | fastq.gz | 10.2 GB |
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| EGAF50000384196 | fastq.gz | 21.0 GB |
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| EGAF50000384197 | fastq.gz | 8.3 GB |
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| EGAF50000384198 | fastq.gz | 17.5 GB |
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| EGAF50000384199 | fastq.gz | 8.5 GB |
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| EGAF50000384200 | fastq.gz | 17.2 GB |
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| EGAF50000384201 | fastq.gz | 6.5 GB |
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| EGAF50000384202 | fastq.gz | 13.0 GB |
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| EGAF50000384203 | fastq.gz | 11.9 GB |
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| EGAF50000384204 | fastq.gz | 25.7 GB |
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| EGAF50000384205 | fastq.gz | 7.0 GB |
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| EGAF50000384206 | fastq.gz | 13.5 GB |
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| EGAF50000384207 | fastq.gz | 5.8 GB |
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| EGAF50000384208 | fastq.gz | 12.0 GB |
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| EGAF50000384209 | fastq.gz | 8.8 GB |
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| EGAF50000384210 | fastq.gz | 15.7 GB |
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| EGAF50000384211 | fastq.gz | 6.2 GB |
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| EGAF50000384212 | fastq.gz | 13.2 GB |
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| EGAF50000384213 | fastq.gz | 9.5 GB |
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| EGAF50000384214 | fastq.gz | 17.9 GB |
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| EGAF50000384215 | fastq.gz | 10.1 GB |
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| EGAF50000384216 | fastq.gz | 21.3 GB |
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| EGAF50000384217 | fastq.gz | 7.6 GB |
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| EGAF50000384218 | fastq.gz | 14.4 GB |
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| EGAF50000384219 | fastq.gz | 9.1 GB |
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| EGAF50000384220 | fastq.gz | 15.8 GB |
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| EGAF50000384221 | fastq.gz | 15.1 GB |
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| EGAF50000384222 | fastq.gz | 27.7 GB |
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| EGAF50000384223 | tsv.gz | 137.0 kB |
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| EGAF50000384224 | tsv.gz | 588.5 kB |
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| EGAF50000384225 | tsv.gz | 7.2 MB |
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| EGAF50000384226 | mtx.gz | 760.1 MB |
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| EGAF50000384227 | fastq.gz | 2.5 GB |
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| EGAF50000384228 | fastq.gz | 5.2 GB |
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| 54 Files (602.5 GB) | ||||
