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Single-nucleus RNA-sequencing data of kidney biopsies from patients with primary FSGS, maladaptive FSGS, proteinuric controls and healthy controls

This dataset includes FASTQ files of single-nucleus RNA sequencing of cryopreserved kidney biopsy cores from adult patients with diagnosed primary FSGS (n = 9, all nephrotic), maladaptive FSGS (n = 9, not nephrotic), proteinuric controls (PLA2R-positive membranous nephropathy, n = 3), and healthy controls (n = 4). A total of 120,751 high-quality nuclei were identified, including 2,471 podocytes and 1,574 parietal epithelial cells (PECs). In addition to the raw FASTQ files, the dataset includes processed data files from all 25 samples, generated using Seurat in R: barcode files, features, count matrices, and associated metadata. Details regarding the bioinformatics pipeline can be found at https://github.com/lambrechtslab/FSGS_Deleersnijder_et_al

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VIB Policy for Data Access and Data Transfer Applicability This policy applies to the access to and transfer of VIB research datasets that contain non-anonymous Personal Data which are subject to the provisions of the General Data Protection Regulation (EU) 2016/679. Access/transfer conditions - The access/transfer is subject to approval by the VIB Data Access Committee. - The proposed research purpose should not be incompatible with the primary research purpose for which the data were originally generated. - The Recipient shall have in place adequate safeguards for the protection of Personal Data. - Access is subject to a Data Transfer/Access Agreement which will be managed by VIB Innovation & Business. - The Data Transfer/Access will be limited to the Data that are necessary for the proposed research. Access/transfer procedure - Requests to access or obtain non-anonymous datasets should be submitted to the responsible corresponding author that has uploaded the dataset into the repository, and with a copy to dac@vib.be. - The request should contain the following information: o Name, affiliation (legal entity) and contact information of the requesting recipient party. o Reference to the specific dataset(s) for which access or transfer is requested. o Description of the research purpose for which the data will be used. - The VIB Data Access Committee takes decisions to approve access/transfer within 14 days upon receipt of the request. - Data access will be given / Data will be transferred after completion of the Data Transfer/Access Agreement.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000001070 RNASeq

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF50000384175 fastq.gz 8.7 GB
EGAF50000384176 fastq.gz 14.9 GB
EGAF50000384177 fastq.gz 11.5 GB
EGAF50000384178 fastq.gz 19.0 GB
EGAF50000384179 fastq.gz 7.7 GB
EGAF50000384180 fastq.gz 11.4 GB
EGAF50000384181 fastq.gz 8.3 GB
EGAF50000384182 fastq.gz 17.3 GB
EGAF50000384183 fastq.gz 5.3 GB
EGAF50000384184 fastq.gz 10.5 GB
EGAF50000384185 fastq.gz 7.6 GB
EGAF50000384186 fastq.gz 16.5 GB
EGAF50000384187 fastq.gz 11.3 GB
EGAF50000384188 fastq.gz 24.0 GB
EGAF50000384189 fastq.gz 4.9 GB
EGAF50000384190 fastq.gz 10.2 GB
EGAF50000384191 fastq.gz 5.6 GB
EGAF50000384192 fastq.gz 11.3 GB
EGAF50000384193 fastq.gz 5.7 GB
EGAF50000384194 fastq.gz 11.9 GB
EGAF50000384195 fastq.gz 10.2 GB
EGAF50000384196 fastq.gz 21.0 GB
EGAF50000384197 fastq.gz 8.3 GB
EGAF50000384198 fastq.gz 17.5 GB
EGAF50000384199 fastq.gz 8.5 GB
EGAF50000384200 fastq.gz 17.2 GB
EGAF50000384201 fastq.gz 6.5 GB
EGAF50000384202 fastq.gz 13.0 GB
EGAF50000384203 fastq.gz 11.9 GB
EGAF50000384204 fastq.gz 25.7 GB
EGAF50000384205 fastq.gz 7.0 GB
EGAF50000384206 fastq.gz 13.5 GB
EGAF50000384207 fastq.gz 5.8 GB
EGAF50000384208 fastq.gz 12.0 GB
EGAF50000384209 fastq.gz 8.8 GB
EGAF50000384210 fastq.gz 15.7 GB
EGAF50000384211 fastq.gz 6.2 GB
EGAF50000384212 fastq.gz 13.2 GB
EGAF50000384213 fastq.gz 9.5 GB
EGAF50000384214 fastq.gz 17.9 GB
EGAF50000384215 fastq.gz 10.1 GB
EGAF50000384216 fastq.gz 21.3 GB
EGAF50000384217 fastq.gz 7.6 GB
EGAF50000384218 fastq.gz 14.4 GB
EGAF50000384219 fastq.gz 9.1 GB
EGAF50000384220 fastq.gz 15.8 GB
EGAF50000384221 fastq.gz 15.1 GB
EGAF50000384222 fastq.gz 27.7 GB
EGAF50000384223 tsv.gz 137.0 kB
EGAF50000384224 tsv.gz 588.5 kB
EGAF50000384225 tsv.gz 7.2 MB
EGAF50000384226 mtx.gz 760.1 MB
EGAF50000384227 fastq.gz 2.5 GB
EGAF50000384228 fastq.gz 5.2 GB
54 Files (602.5 GB)