Mutational signatures in normal tissues of patients treated with clinical stage G-quadruplex binder CX5461
Drug induced photoreactions following exposure to UVA have been documented for several therapeutic compound classes, including psoralens and fluoroquinolones. We used deep (~80X) whole genome sequencing to examine the mutagenic spectrum of CX5461, quinolone-derived small molecule, in normal tissues of cancer patients undergoing treatment. We compared the distribution of somatic base substitutions and short indels from skin biopsies taken from non-sun exposed areas pre and post CX5461 exposure of patients. To further characterize the mutational pattern of CX5461 photoreactivity, we compared mutational profiles of human retinal pigment epithelial cells exposed to UVA, CX5461, or a combination of both UV and CX5461.
- 20/08/2025
- 38 samples
- DAC: EGAC00000000011
- Technologies: Illumina HiSeq X, Illumina NovaSeq X
DUO:0000012 version: 2021-02-23
research specific restrictions
This data use modifier indicates that use is limited to studies of a certain research type.
DUO:0000025 version: 2021-02-23
time limit on use
This data use modifier indicates that use is approved for a specific number of months.
BC Cancer, part of the Provincial Health Services Authority - Data Access Policy
Access to this data is controlled. There are a number of steps that a researcher must take to obtain access to this data, including execution of a Data Access Agreement between the institutions. The process is overseen by the Technology Development Office; please contact our general email address TDOadmin@phsa.ca. Please only click the "request data" button on the EGA website after a Data Access Agreement is fully executed.
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS50000001145 | Whole Genome Sequencing |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
Located in
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|---|---|---|---|---|
| EGAF50000404470 | bam | 123.2 GB |
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| EGAF50000404471 | bai | 9.5 MB |
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| EGAF50000404472 | bai | 9.7 MB |
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| EGAF50000404473 | bam | 157.9 GB |
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| EGAF50000404474 | bai | 9.7 MB |
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| EGAF50000404475 | bam | 123.1 GB |
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| EGAF50000404476 | bai | 9.6 MB |
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| EGAF50000404477 | bam | 110.5 GB |
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| EGAF50000404478 | bam | 112.6 GB |
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| EGAF50000404479 | bai | 9.6 MB |
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| EGAF50000404480 | bai | 9.5 MB |
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| EGAF50000404481 | bam | 105.1 GB |
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| EGAF50000404482 | bam | 111.2 GB |
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| EGAF50000404483 | bai | 9.6 MB |
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| EGAF50000404484 | bai | 9.6 MB |
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| EGAF50000404485 | bam | 111.5 GB |
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| EGAF50000404486 | bam | 119.3 GB |
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| EGAF50000404487 | bai | 9.6 MB |
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| EGAF50000404488 | bai | 9.6 MB |
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| EGAF50000404489 | bam | 112.5 GB |
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| EGAF50000404490 | bai | 9.6 MB |
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| EGAF50000404491 | bam | 116.8 GB |
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| EGAF50000404492 | bai | 9.6 MB |
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| EGAF50000404493 | bam | 27.2 GB |
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| EGAF50000404494 | bai | 9.6 MB |
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| EGAF50000404495 | bam | 4.6 GB |
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| EGAF50000404496 | bam | 62.9 GB |
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| EGAF50000404497 | bai | 9.6 MB |
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| EGAF50000404498 | bai | 9.6 MB |
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| EGAF50000404499 | bam | 113.1 GB |
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| EGAF50000404500 | bai | 8.9 MB |
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| EGAF50000404501 | bam | 96.5 GB |
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| EGAF50000404502 | bai | 9.6 MB |
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| EGAF50000404503 | bam | 109.2 GB |
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| EGAF50000404504 | bai | 9.5 MB |
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| EGAF50000404505 | bam | 119.4 GB |
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| EGAF50000404506 | bam | 134.7 GB |
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| EGAF50000404507 | bai | 9.6 MB |
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| EGAF50000404508 | bai | 8.9 MB |
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| EGAF50000404509 | bam | 101.4 GB |
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| EGAF50000404510 | bai | 9.5 MB |
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| EGAF50000404511 | bam | 114.6 GB |
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| EGAF50000404512 | bam | 107.2 GB |
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| EGAF50000404513 | bai | 9.6 MB |
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| EGAF50000404514 | bam | 113.1 GB |
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| EGAF50000404515 | bai | 9.6 MB |
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| EGAF50000404516 | bam | 121.4 GB |
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| EGAF50000404517 | bai | 9.7 MB |
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| EGAF50000404518 | bam | 108.2 GB |
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| EGAF50000404519 | bai | 9.6 MB |
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| EGAF50000404520 | bai | 9.6 MB |
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| EGAF50000404521 | bam | 110.0 GB |
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| EGAF50000404522 | bam | 114.8 GB |
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| EGAF50000404523 | bai | 9.6 MB |
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| EGAF50000404524 | bai | 9.6 MB |
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| EGAF50000404525 | bam | 109.9 GB |
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| EGAF50000404526 | bai | 9.6 MB |
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| EGAF50000404527 | bam | 106.3 GB |
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| EGAF50000404528 | bai | 9.6 MB |
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| EGAF50000404529 | bam | 106.4 GB |
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| EGAF50000404530 | bam | 103.4 GB |
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| EGAF50000404531 | bai | 9.6 MB |
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| EGAF50000404532 | bai | 9.6 MB |
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| EGAF50000404533 | bam | 114.7 GB |
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| EGAF50000404534 | bai | 9.6 MB |
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| EGAF50000404535 | bam | 110.6 GB |
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| EGAF50000404536 | bai | 9.5 MB |
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| EGAF50000404537 | bam | 112.2 GB |
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| EGAF50000404538 | bai | 9.6 MB |
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| EGAF50000404539 | bam | 106.2 GB |
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| EGAF50000404540 | bai | 9.6 MB |
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| EGAF50000404541 | bam | 126.4 GB |
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| EGAF50000404542 | bai | 9.6 MB |
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| EGAF50000404543 | bam | 110.2 GB |
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| EGAF50000404544 | bai | 9.5 MB |
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| EGAF50000404545 | bam | 109.2 GB |
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| EGAF50000404546 | vcf | 575.8 kB |
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| EGAF50000404547 | idx | 136.6 kB |
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| EGAF50000404548 | vcf | 384.3 kB |
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| EGAF50000404549 | idx | 130.1 kB |
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| EGAF50000404550 | vcf | 2.7 MB |
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| EGAF50000404551 | vcf | 5.1 MB |
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| EGAF50000404552 | idx | 138.9 kB |
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| EGAF50000404553 | vcf | 535.4 kB |
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| EGAF50000404554 | vcf | 388.9 kB |
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| EGAF50000404555 | idx | 134.2 kB |
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| EGAF50000404556 | vcf | 419.5 kB |
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| EGAF50000404557 | idx | 135.0 kB |
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| EGAF50000404558 | vcf | 414.1 kB |
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| EGAF50000404559 | idx | 132.7 kB |
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| EGAF50000404560 | vcf | 12.1 MB |
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| EGAF50000404561 | idx | 138.8 kB |
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| EGAF50000404562 | vcf | 542.1 kB |
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| EGAF50000404563 | idx | 137.4 kB |
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| EGAF50000404564 | vcf | 410.0 kB |
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| EGAF50000404565 | idx | 134.5 kB |
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| EGAF50000404566 | vcf | 449.1 kB |
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| EGAF50000404567 | idx | 138.6 kB |
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| EGAF50000404568 | vcf | 387.3 kB |
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| EGAF50000404569 | idx | 134.1 kB |
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| EGAF50000404570 | vcf | 456.3 kB |
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| EGAF50000404571 | idx | 135.2 kB |
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| EGAF50000404572 | idx | 132.1 kB |
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| EGAF50000404573 | vcf | 371.5 kB |
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| EGAF50000404574 | idx | 184.3 kB |
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| EGAF50000404575 | vcf | 167.4 MB |
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| EGAF50000404576 | vcf | 370.5 kB |
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| EGAF50000404577 | vcf | 382.3 kB |
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| EGAF50000404578 | idx | 134.2 kB |
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| EGAF50000404579 | vcf | 436.5 kB |
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| EGAF50000404580 | idx | 135.1 kB |
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| EGAF50000404581 | idx | 134.2 kB |
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| EGAF50000404582 | vcf | 542.9 kB |
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| EGAF50000404583 | idx | 137.2 kB |
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| EGAF50000404584 | idx | 131.1 kB |
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| EGAF50000404585 | idx | 134.7 kB |
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| EGAF50000404586 | vcf | 456.7 kB |
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| EGAF50000404587 | idx | 136.1 kB |
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| 118 Files (4.1 TB) | ||||