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The brain neurovascular epigenome and its association with dementia

H3K27Ac and H3K4me3 CUT&Tag fastq data using resected tissue from 6 cell types: Microglia (PU1+), Brain endothelial cells (ERG+), Mural cells (NOTCH3+), Neurons (NEUN+), Oligodendrocytes (OLIG2+) and Astrocytes (RFX4+). Transcription factor CUT&Tag for PU1, ERG and OLIG2. Promoter capture HiC for Primary pericytes, Primary Brain endothelial cells and Astrocytes.

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DUO:0000006
version: 2021-02-23

health or medical or biomedical research

This data use permission indicates that use is allowed for health/medical/biomedical purposes; does not include the study of population origins or ancestry.

Brain gene regulatory data access policy

These terms and conditions govern access to the managed access datasets to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. NGDAC: Nott Group DAC. 1. The User Institution agrees to only use these Data for the purpose of the Project described and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations set out. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the MRC Data Sharing Policy https://www.ukri.org/publications/mrc-data-sharing-policy/data-sharing-policy/ 8. The User Institution agrees to follow the Publication Policy. This includes respecting the moratorium period. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 11. The User Institution will notify NGDAC within 30 days of any changes or departures of Authorised Personnel. 12. The User Institution will notify NGDAC prior to any significant changes to the protocol for the Project. 13. The User Institution will notify NGDAC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 14. NGDAC may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 15. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than NGDAC. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 16. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 17. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 18. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the exclusive jurisdiction of the English courts.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000001160 Epigenetics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF50000406852 fastq.gz 251.4 MB
EGAF50000406853 fastq.gz 268.1 MB
EGAF50000406854 fastq.gz 471.3 MB
EGAF50000406855 fastq.gz 481.7 MB
EGAF50000406856 fastq.gz 802.2 MB
EGAF50000406857 fastq.gz 820.0 MB
EGAF50000406858 fastq.gz 629.7 MB
EGAF50000406859 fastq.gz 800.2 MB
EGAF50000406860 fastq.gz 315.6 MB
EGAF50000406861 fastq.gz 396.2 MB
EGAF50000406862 fastq.gz 400.3 MB
EGAF50000406863 fastq.gz 318.2 MB
EGAF50000406864 fastq.gz 441.2 MB
EGAF50000406865 fastq.gz 351.3 MB
EGAF50000406866 fastq.gz 398.7 MB
EGAF50000406867 fastq.gz 406.6 MB
EGAF50000406868 fastq.gz 451.3 MB
EGAF50000406869 fastq.gz 454.1 MB
EGAF50000406870 fastq.gz 329.9 MB
EGAF50000406871 fastq.gz 338.0 MB
EGAF50000406872 fastq.gz 361.2 MB
EGAF50000406873 fastq.gz 460.0 MB
EGAF50000406874 fastq.gz 252.8 MB
EGAF50000406875 fastq.gz 587.1 MB
EGAF50000406876 fastq.gz 488.4 MB
EGAF50000406877 fastq.gz 300.5 MB
EGAF50000406878 fastq.gz 304.9 MB
EGAF50000406879 fastq.gz 333.0 MB
EGAF50000406880 fastq.gz 334.6 MB
EGAF50000406881 fastq.gz 896.7 MB
EGAF50000406882 fastq.gz 904.3 MB
EGAF50000406883 fastq.gz 943.3 MB
EGAF50000406884 fastq.gz 330.4 MB
EGAF50000406885 fastq.gz 948.7 MB
EGAF50000406886 fastq.gz 581.5 MB
EGAF50000406887 fastq.gz 190.3 MB
EGAF50000406888 fastq.gz 260.0 MB
EGAF50000406889 fastq.gz 258.3 MB
EGAF50000406890 fastq.gz 337.8 MB
EGAF50000406891 fastq.gz 865.5 MB
EGAF50000406892 fastq.gz 872.3 MB
EGAF50000406893 fastq.gz 622.8 MB
EGAF50000406894 fastq.gz 609.0 MB
EGAF50000406895 fastq.gz 639.5 MB
EGAF50000406896 fastq.gz 405.1 MB
EGAF50000406897 fastq.gz 415.8 MB
EGAF50000406898 fastq.gz 420.5 MB
EGAF50000406899 fastq.gz 541.9 MB
EGAF50000406900 fastq.gz 546.1 MB
EGAF50000406901 fastq.gz 389.1 MB
EGAF50000406902 fastq.gz 389.1 MB
EGAF50000406903 fastq.gz 367.2 MB
EGAF50000406904 fastq.gz 445.7 MB
EGAF50000406905 fastq.gz 316.2 MB
EGAF50000406906 fastq.gz 317.3 MB
EGAF50000406907 fastq.gz 300.9 MB
EGAF50000406908 fastq.gz 308.7 MB
EGAF50000406909 fastq.gz 300.0 MB
EGAF50000406910 fastq.gz 301.9 MB
EGAF50000406911 fastq.gz 298.1 MB
EGAF50000406912 fastq.gz 555.2 MB
EGAF50000406913 fastq.gz 562.3 MB
EGAF50000406914 fastq.gz 323.7 MB
EGAF50000406915 fastq.gz 551.3 MB
EGAF50000406916 fastq.gz 596.7 MB
EGAF50000406917 fastq.gz 595.4 MB
EGAF50000406918 fastq.gz 625.5 MB
EGAF50000406919 fastq.gz 415.9 MB
EGAF50000406920 fastq.gz 279.4 MB
EGAF50000406921 fastq.gz 440.2 MB
EGAF50000406922 fastq.gz 418.8 MB
EGAF50000406923 fastq.gz 441.1 MB
EGAF50000406924 fastq.gz 302.8 MB
EGAF50000406925 fastq.gz 309.4 MB
EGAF50000406926 fastq.gz 730.3 MB
EGAF50000406927 fastq.gz 750.9 MB
EGAF50000406928 fastq.gz 298.9 MB
EGAF50000406929 fastq.gz 303.8 MB
EGAF50000406930 fastq.gz 322.5 MB
EGAF50000406931 fastq.gz 755.2 MB
EGAF50000406932 fastq.gz 774.5 MB
EGAF50000406933 fastq.gz 495.1 MB
EGAF50000406934 fastq.gz 519.1 MB
EGAF50000406935 fastq.gz 451.3 MB
EGAF50000406936 fastq.gz 457.9 MB
EGAF50000406937 fastq.gz 440.6 MB
EGAF50000406938 fastq.gz 446.3 MB
EGAF50000406939 fastq.gz 508.9 MB
EGAF50000406940 fastq.gz 532.2 MB
EGAF50000406941 fastq.gz 338.4 MB
EGAF50000406942 fastq.gz 936.2 MB
EGAF50000406943 fastq.gz 600.2 MB
EGAF50000406944 fastq.gz 603.0 MB
EGAF50000406945 fastq.gz 577.2 MB
EGAF50000406946 fastq.gz 554.0 MB
EGAF50000406947 fastq.gz 579.4 MB
EGAF50000406948 fastq.gz 565.3 MB
EGAF50000406949 fastq.gz 771.9 MB
EGAF50000406950 fastq.gz 792.8 MB
EGAF50000406951 fastq.gz 505.0 MB
EGAF50000406952 fastq.gz 535.9 MB
EGAF50000406953 fastq.gz 315.4 MB
EGAF50000406954 fastq.gz 259.3 MB
EGAF50000406955 fastq.gz 463.6 MB
EGAF50000406956 fastq.gz 476.1 MB
EGAF50000406957 fastq.gz 439.5 MB
EGAF50000406958 fastq.gz 449.2 MB
EGAF50000406959 fastq.gz 450.4 MB
EGAF50000406960 fastq.gz 789.9 MB
EGAF50000406961 fastq.gz 321.6 MB
EGAF50000406962 fastq.gz 353.5 MB
EGAF50000406963 fastq.gz 373.4 MB
EGAF50000406964 fastq.gz 373.9 MB
EGAF50000406965 fastq.gz 387.5 MB
EGAF50000406966 fastq.gz 586.0 MB
EGAF50000406967 fastq.gz 590.3 MB
EGAF50000406968 fastq.gz 537.0 MB
EGAF50000406969 fastq.gz 555.7 MB
EGAF50000406970 fastq.gz 568.6 MB
EGAF50000406971 fastq.gz 176.3 MB
EGAF50000406972 fastq.gz 181.1 MB
EGAF50000406973 fastq.gz 342.8 MB
EGAF50000406974 fastq.gz 421.5 MB
EGAF50000406975 fastq.gz 438.8 MB
EGAF50000406976 fastq.gz 449.2 MB
EGAF50000406977 fastq.gz 465.2 MB
EGAF50000406978 fastq.gz 939.3 MB
EGAF50000406979 fastq.gz 345.8 MB
EGAF50000406980 fastq.gz 178.3 MB
EGAF50000406981 fastq.gz 184.4 MB
EGAF50000406982 fastq.gz 858.4 MB
EGAF50000406983 fastq.gz 814.7 MB
EGAF50000406984 fastq.gz 567.2 MB
EGAF50000406985 fastq.gz 836.6 MB
EGAF50000406986 fastq.gz 431.2 MB
EGAF50000406987 fastq.gz 549.0 MB
EGAF50000406988 fastq.gz 556.5 MB
EGAF50000406989 fastq.gz 346.2 MB
EGAF50000406990 fastq.gz 358.2 MB
EGAF50000406991 fastq.gz 380.9 MB
EGAF50000406992 fastq.gz 389.5 MB
EGAF50000406993 fastq.gz 820.0 MB
EGAF50000406994 fastq.gz 537.0 MB
EGAF50000406995 fastq.gz 14.1 GB
EGAF50000406996 fastq.gz 14.8 GB
EGAF50000406997 fastq.gz 14.7 GB
EGAF50000406998 fastq.gz 327.3 MB
EGAF50000406999 fastq.gz 286.8 MB
EGAF50000407000 fastq.gz 330.6 MB
EGAF50000407001 fastq.gz 352.2 MB
EGAF50000407002 fastq.gz 157.5 MB
EGAF50000407003 fastq.gz 164.4 MB
EGAF50000407004 fastq.gz 18.0 GB
EGAF50000407005 fastq.gz 19.2 GB
EGAF50000407006 fastq.gz 15.1 GB
EGAF50000407007 fastq.gz 16.2 GB
EGAF50000407008 fastq.gz 28.8 GB
EGAF50000407009 fastq.gz 30.7 GB
EGAF50000407010 fastq.gz 29.5 GB
EGAF50000407011 fastq.gz 31.7 GB
EGAF50000407012 fastq.gz 465.5 MB
EGAF50000407013 fastq.gz 431.0 MB
EGAF50000407014 fastq.gz 454.4 MB
EGAF50000407015 fastq.gz 439.3 MB
EGAF50000407016 fastq.gz 631.7 MB
EGAF50000407017 fastq.gz 783.8 MB
EGAF50000407018 fastq.gz 592.9 MB
EGAF50000407019 fastq.gz 630.7 MB
EGAF50000407020 fastq.gz 596.4 MB
EGAF50000407021 fastq.gz 776.1 MB
EGAF50000407022 fastq.gz 13.4 GB
EGAF50000407023 fastq.gz 17.6 GB
EGAF50000407024 fastq.gz 18.7 GB
EGAF50000407025 fastq.gz 1.1 GB
EGAF50000407026 fastq.gz 186.1 MB
EGAF50000407027 fastq.gz 251.3 MB
EGAF50000407028 fastq.gz 248.6 MB
EGAF50000407029 fastq.gz 333.1 MB
EGAF50000407030 fastq.gz 334.7 MB
EGAF50000407031 fastq.gz 332.7 MB
EGAF50000407032 fastq.gz 298.5 MB
EGAF50000407033 fastq.gz 322.9 MB
EGAF50000407034 fastq.gz 574.6 MB
EGAF50000407035 fastq.gz 336.5 MB
EGAF50000407036 fastq.gz 1.0 GB
EGAF50000407037 fastq.gz 1.1 GB
EGAF50000407038 fastq.gz 1.0 GB
EGAF50000407039 fastq.gz 340.3 MB
EGAF50000407040 fastq.gz 601.6 MB
EGAF50000407041 fastq.gz 605.9 MB
EGAF50000407042 fastq.gz 633.3 MB
EGAF50000407043 fastq.gz 683.9 MB
EGAF50000407044 fastq.gz 647.6 MB
EGAF50000407045 fastq.gz 323.7 MB
EGAF50000407046 fastq.gz 260.3 MB
EGAF50000407047 fastq.gz 384.5 MB
EGAF50000407048 fastq.gz 401.7 MB
EGAF50000407049 fastq.gz 543.2 MB
EGAF50000407050 fastq.gz 248.7 MB
EGAF50000407051 fastq.gz 260.4 MB
EGAF50000407052 fastq.gz 263.4 MB
EGAF50000407053 fastq.gz 483.0 MB
EGAF50000407054 fastq.gz 506.8 MB
EGAF50000407055 fastq.gz 503.4 MB
EGAF50000407056 fastq.gz 328.6 MB
EGAF50000407057 fastq.gz 298.3 MB
EGAF50000407058 fastq.gz 306.0 MB
EGAF50000407059 fastq.gz 396.9 MB
EGAF50000407060 fastq.gz 334.2 MB
EGAF50000407061 fastq.gz 386.2 MB
EGAF50000407062 fastq.gz 404.3 MB
EGAF50000407063 fastq.gz 326.1 MB
EGAF50000407064 fastq.gz 15.5 GB
EGAF50000407065 fastq.gz 14.1 GB
214 Files (406.8 GB)