About file location

As the EGA is co-managed by the EMBL-EBI and CRG, files could be located in the UK and/or Spain, as indicated by their respective flags.

Alternatively, files could be located in one of the international Federated EGA nodes, as indicated next to the node's flag.
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Dynamics of checkpoint receptors in γδ T cell subsets are associated with clinical responses during anti-PD-1 immunotherapies

scRNA-seq data from circulating gamma delta T cells derived from healthy donors and patients with stage IV melanoma that either responded or did not respond to anti-PD-1 monotherapy or anti-PD-1 and anti-CTLA-4 combination therapy. This dataset includes paired samples from these patients before and 3 months after the start of immunotherapy.

Request Access

DUO:0000020
version: 2021-02-23

collaboration required

This data use modifier indicates that the requestor must agree to collaboration with the primary study investigator(s).

DUO:0000026
version: 2021-02-23

user specific restriction

This data use modifier indicates that use is limited to use by approved users.

DUO:0000027
version: 2021-02-23

project specific restriction

This data use modifier indicates that use is limited to use within an approved project.

Data Access Policy CCIT-DK

Data Access Policy Introduction These terms and conditions govern access to the managed access datasets to which the Research Group has requested access. The Research Group agrees to be bound by these terms and conditions. Access to the Data will be reviewed on individual basis. Further, access to the Data may only be granted to requests that align with the ethical approval for these Data, and only within collaborative proposals to be outlined in a Data processing agreement, as per approved protocol. Definitions Authorised Personnel: The individuals in the Research Group to whom CCIT-DK DAC grants access to the Data. This includes the User and any other individuals for whom the Research Group subsequently requests access to the Data. Data: The managed access datasets to which the Research Group has requested access. Data Producers: CCIT-DK DAC and the collaborators responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for a Research Group other than the Research Group applying for data access. Project: The project for which the Research Group has requested access to these Data. A description of the Project is set out in Appendix I. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. Research group(s): The Research Group that has requested access to the Data. CCIT-DK DAC: Principal Investigators Marco Donia, MD PhD, and Inge Marie Svane, MD PhD, National Center for Cancer Immune Therapy Denmark (CCIT-DK), Copenhagen University Hospital Herlev. Data Access Policy main terms 1. The Research Group agrees to only use these Data for the purpose of the Project (described in Appendix I) and only for Research Purposes. The Research Group further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The Research Group agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. 3. The Research Group agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The Research Group agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the Research Group or is freely available without restriction. 5. The Research Group agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The Research Group agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The Research Group agrees to follow the Fort Lauderdale Guidelines on Sharing Data from Large-scale Biological Research Projects (Report of a meeting organized by the Wellcome Trust and held on 14–15 January 2003 at Fort Lauderdale, USA) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes, but is not limited to, recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The Research Group agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 9. The Research Group can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the Research Group agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.govinfo.gov/content/pkg/FR-2004-11-19/pdf/04-25671.pdf) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 10. The Research Group agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 11. The Research Group will notify CCIT-DK DAC within 30 days of any changes or departures of Authorised Personnel. 12. The Research Group will notify CCIT-DK DAC prior to any significant changes to the protocol for the Project. 13. The Research Group will notify CCIT-DK DAC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 14. CCIT-DK DAC may terminate this agreement by written notice to the Research Group. If this agreement terminates for any reason, the Research Group will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the Research Group from retaining these data for archival purpose in conformity with audit or legal requirements. 15. The Research Group accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than CCIT-DK DAC. In the event that changes are required, the Data Producers or their appointed agent will contact the Research Group to inform it of the changes and the Research Group may elect to accept the changes or terminate the agreement. 16. If requested, the Research Group will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 17. The Research Group agrees to distribute a copy of these terms to the Authorised Personnel. The Research Group will procure that the Authorised Personnel comply with the terms of this agreement.   APPENDIX I – PROJECT DETAILS (to be completed by the Requestor / Research Group) Details of dataset requested i.e., EGA Study and Dataset Accession Number Brief abstract of the Project in which the Data will be used (500 words max) All Individuals who the Research Group to be named as registered users Name of Registered User Email Job Title Supervisor*

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000001270 Transcriptome Analysis

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
i
EGAF50000432762 fastq.gz 516.1 MB
EGAF50000432763 fastq.gz 255.7 MB
EGAF50000432764 fastq.gz 202.5 MB
EGAF50000432765 fastq.gz 406.9 MB
EGAF50000432766 fastq.gz 3.1 GB
EGAF50000432767 fastq.gz 7.6 GB
EGAF50000432768 fastq.gz 313.0 MB
EGAF50000432769 fastq.gz 705.8 MB
EGAF50000432770 fastq.gz 766.9 MB
EGAF50000432771 fastq.gz 339.1 MB
EGAF50000432772 fastq.gz 229.3 MB
EGAF50000432773 fastq.gz 522.0 MB
EGAF50000432774 fastq.gz 521.4 MB
EGAF50000432775 fastq.gz 229.3 MB
EGAF50000432776 fastq.gz 506.9 MB
EGAF50000432777 fastq.gz 239.5 MB
EGAF50000432778 fastq.gz 548.3 MB
EGAF50000432779 fastq.gz 222.0 MB
EGAF50000432780 fastq.gz 219.3 MB
EGAF50000432781 fastq.gz 458.4 MB
EGAF50000432782 fastq.gz 458.2 MB
EGAF50000432783 fastq.gz 219.2 MB
EGAF50000432784 fastq.gz 8.2 GB
EGAF50000432785 fastq.gz 2.3 GB
EGAF50000432786 fastq.gz 9.0 GB
EGAF50000432787 fastq.gz 2.0 GB
EGAF50000432788 fastq.gz 3.2 GB
EGAF50000432789 fastq.gz 3.2 GB
EGAF50000432790 fastq.gz 12.6 GB
EGAF50000432791 fastq.gz 12.8 GB
EGAF50000432792 fastq.gz 557.8 MB
EGAF50000432793 fastq.gz 1.1 GB
EGAF50000432794 fastq.gz 445.6 MB
EGAF50000432795 fastq.gz 908.6 MB
EGAF50000432796 fastq.gz 4.2 GB
EGAF50000432797 fastq.gz 10.5 GB
EGAF50000432798 fastq.gz 677.9 MB
EGAF50000432799 fastq.gz 323.8 MB
EGAF50000432800 fastq.gz 732.6 MB
EGAF50000432801 fastq.gz 300.5 MB
EGAF50000432802 fastq.gz 304.5 MB
EGAF50000432803 fastq.gz 685.4 MB
EGAF50000432804 fastq.gz 622.6 MB
EGAF50000432805 fastq.gz 277.7 MB
EGAF50000432806 fastq.gz 320.4 MB
EGAF50000432807 fastq.gz 708.1 MB
EGAF50000432808 fastq.gz 320.2 MB
EGAF50000432809 fastq.gz 708.2 MB
EGAF50000432810 fastq.gz 464.8 MB
EGAF50000432811 fastq.gz 200.2 MB
EGAF50000432812 fastq.gz 431.6 MB
EGAF50000432813 fastq.gz 214.6 MB
EGAF50000432814 fastq.gz 482.6 MB
EGAF50000432815 fastq.gz 212.2 MB
EGAF50000432816 fastq.gz 445.5 MB
EGAF50000432817 fastq.gz 228.9 MB
EGAF50000432818 fastq.gz 1.4 GB
EGAF50000432819 fastq.gz 5.7 GB
EGAF50000432820 fastq.gz 5.6 GB
EGAF50000432821 fastq.gz 1.5 GB
EGAF50000432822 fastq.gz 1.5 GB
EGAF50000432823 fastq.gz 5.8 GB
EGAF50000432824 fastq.gz 1.4 GB
EGAF50000432825 fastq.gz 5.5 GB
EGAF50000432826 fastq.gz 7.3 GB
EGAF50000432827 fastq.gz 7.3 GB
EGAF50000432828 fastq.gz 1.9 GB
EGAF50000432829 fastq.gz 1.9 GB
EGAF50000432830 fastq.gz 412.4 MB
EGAF50000432831 fastq.gz 852.2 MB
EGAF50000432832 fastq.gz 8.3 GB
EGAF50000432833 fastq.gz 3.4 GB
EGAF50000432834 fastq.gz 11.5 GB
EGAF50000432835 fastq.gz 4.7 GB
EGAF50000432836 fastq.gz 697.3 MB
EGAF50000432837 fastq.gz 309.8 MB
EGAF50000432838 fastq.gz 309.8 MB
EGAF50000432839 fastq.gz 696.5 MB
EGAF50000432840 fastq.gz 220.3 MB
EGAF50000432841 fastq.gz 543.1 MB
EGAF50000432842 fastq.gz 235.8 MB
EGAF50000432843 fastq.gz 505.9 MB
EGAF50000432844 fastq.gz 646.9 MB
EGAF50000432845 fastq.gz 290.6 MB
EGAF50000432846 fastq.gz 290.9 MB
EGAF50000432847 fastq.gz 648.1 MB
EGAF50000432848 fastq.gz 442.9 MB
EGAF50000432849 fastq.gz 205.8 MB
EGAF50000432850 fastq.gz 442.1 MB
EGAF50000432851 fastq.gz 206.0 MB
EGAF50000432852 fastq.gz 2.3 GB
EGAF50000432853 fastq.gz 9.0 GB
EGAF50000432854 fastq.gz 2.3 GB
EGAF50000432855 fastq.gz 9.1 GB
EGAF50000432856 fastq.gz 9.5 GB
EGAF50000432857 fastq.gz 2.2 GB
EGAF50000432858 fastq.gz 8.5 GB
EGAF50000432859 fastq.gz 2.4 GB
EGAF50000432860 fastq.gz 9.3 GB
EGAF50000432861 fastq.gz 3.8 GB
EGAF50000432862 fastq.gz 226.5 MB
EGAF50000432863 fastq.gz 226.3 MB
EGAF50000432864 fastq.gz 518.9 MB
EGAF50000432865 fastq.gz 518.1 MB
EGAF50000432866 fastq.gz 323.8 MB
EGAF50000432867 fastq.gz 727.9 MB
EGAF50000432868 fastq.gz 727.3 MB
EGAF50000432869 fastq.gz 323.9 MB
EGAF50000432870 fastq.gz 288.8 MB
EGAF50000432871 fastq.gz 288.9 MB
EGAF50000432872 fastq.gz 646.1 MB
EGAF50000432873 fastq.gz 645.1 MB
EGAF50000432874 fastq.gz 690.8 MB
EGAF50000432875 fastq.gz 311.4 MB
EGAF50000432876 fastq.gz 332.5 MB
EGAF50000432877 fastq.gz 739.9 MB
EGAF50000432878 fastq.gz 631.1 MB
EGAF50000432879 fastq.gz 684.1 MB
EGAF50000432880 fastq.gz 282.3 MB
EGAF50000432881 fastq.gz 305.1 MB
EGAF50000432882 fastq.gz 2.2 GB
EGAF50000432883 fastq.gz 2.2 GB
EGAF50000432884 fastq.gz 8.7 GB
EGAF50000432885 fastq.gz 8.8 GB
EGAF50000432886 fastq.gz 7.0 GB
EGAF50000432887 fastq.gz 1.9 GB
EGAF50000432888 fastq.gz 1.8 GB
EGAF50000432889 fastq.gz 7.5 GB
EGAF50000432890 fastq.gz 1.7 GB
EGAF50000432891 fastq.gz 6.6 GB
EGAF50000432892 fastq.gz 1.7 GB
EGAF50000432893 fastq.gz 6.7 GB
EGAF50000432894 fastq.gz 1.7 GB
EGAF50000432895 fastq.gz 6.8 GB
EGAF50000432896 fastq.gz 6.4 GB
EGAF50000432897 fastq.gz 1.6 GB
EGAF50000432898 fastq.gz 1.5 GB
EGAF50000432899 fastq.gz 5.8 GB
EGAF50000432900 fastq.gz 1.5 GB
EGAF50000432901 fastq.gz 5.8 GB
EGAF50000432902 fastq.gz 1.5 GB
EGAF50000432903 fastq.gz 5.8 GB
EGAF50000432904 fastq.gz 3.3 GB
EGAF50000432905 fastq.gz 13.1 GB
EGAF50000432906 fastq.gz 12.1 GB
EGAF50000432907 fastq.gz 3.0 GB
EGAF50000432908 fastq.gz 417.9 MB
EGAF50000432909 fastq.gz 1.6 GB
EGAF50000432910 fastq.gz 421.2 MB
EGAF50000432911 fastq.gz 1.6 GB
EGAF50000432912 fastq.gz 882.0 MB
EGAF50000432913 fastq.gz 889.6 MB
EGAF50000432914 fastq.gz 3.4 GB
EGAF50000432915 fastq.gz 3.4 GB
EGAF50000432916 fastq.gz 423.7 MB
EGAF50000432917 fastq.gz 1.6 GB
EGAF50000432918 fastq.gz 406.5 MB
EGAF50000432919 fastq.gz 1.6 GB
EGAF50000432920 fastq.gz 852.5 MB
EGAF50000432921 fastq.gz 3.3 GB
EGAF50000432922 fastq.gz 899.7 MB
EGAF50000432923 fastq.gz 3.4 GB
162 Files (400.7 GB)