Lung_Cancer_Whole_Genomes
We propose to definitively characterise the somatic genetics of Lung cancer through generation of comprehensive catalogues of somatic mutations by high coverage genome sequencing.
Study
EGAS00001000148
HKU Gastric Cancer Genomics study - WGS, DNA genotyping array, expression and methylation profiling
HKU Gastric Cancer Genomics study - Whole Genome Sequencing, DNA genotyping array, Expression profiling and Methylation profiling
Study
EGAS00001000597
GEL_WGS_Comparison
These samples are to be analysed with the CGP Developed cancer panel and the results will be compared with WGS data from 4 different comercial providers.
Study
EGAS00001000649
The evolutionary dynamics of human colorectal cancer using single-gland spatial multi-omic profiling of DNA, RNA and chromatin.
Deciphering the mechanisms of colorectal cancer growth, progression and dissemination in each individual patient.
Study
EGAS00001005230
Bone metastatic biopsies of breast cancer patients progressing on endocrine therapies.
Study
EGAS00001004268
Detailed molecular and immune marker profiling of archival prostate cancer samples
Study
EGAS00001004396
Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer
Study
EGAS00001006648
CAGEKID: Cancer Genomics of the Kidney
Study
EGAS00001000083
Extreme intratumor heterogeneity and driver evolution in mismatch repair deficient gastro-esophageal cancer
Study
EGAS00001003434
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells
Study
EGAS00001007026
CLL_cancer_Sample_Sequencing
Genomic libraries (500 bps) will be generated from total genomic DNA derived from CLL cancer samples and subjected to total of eight lanes of 37 bp, paired end sequencing on the llumina GA. Paired reads will be mapped to build 37 of the human reference genome to facilitate the generation of genome wide copy number information, and the identification of novel rearranged cancer genes and gene fusions.
Study
EGAS00001000011
Low T cell diversity is associated with poor outcome in bladder cancer - Total RNAseq data
T cells are crucial effector cells in the endogenous defense against cancer, yet the clinical impact of their quantity, diversity, and dynamics remains underexplored. In this study we performed total RNAseq on blood samples from 8 patients with muscle invasive bladder cancer. The goal was to compare blood T cell subtype composition between patients with low and high TCR diversity.
Study
EGAS50000000939
Canadian prostate cancer samples (CPC-GENE) for PanProstate study
CPC-GENE has sequenced the genomes of 350 intermediate risk prostate cancers to identify genetic signatures that differ in cancers that responded well to treatment compared with those that did not. CPC-GENE also has sequenced multiple regions of prostate cancer from the same gland to determine if and how the genetic make-up of prostate cancer varies within an individual man’s prostate
Study
EGAS00001003037
Analysis of Loose Ends in Cancer Genome Structure
Short-read sequencing (SRS) forms the basis of our understanding of cancer genome evolution, yet it is widely thought to be inadequate for detecting structural variants (SVs). To understand the nature of cancer SVs missed by SRS, we introduce the concept of "loose ends" - sites of missing rearrangements revealed by balancing copy number (CN) across the genomic intervals and adjacencies of a genome graph.
Study
EGAS00001007324
Glioma_cell_lines_rearrangement_screen
Genomic libraries (500 bps) will be generated from total genomic DNA derived from commomon epithelial cancer samples and subjected to total of eight lanes of 37 bp, paired end sequencing on the llumina GA. Paired reads will be mapped to build 37 of the human reference genome to facilitate the generation of genome wide copy number information, and the identification of novel rearranged cancer genes and gene fusions.
Study
EGAS00001000202
Renal_Follow_Up_Series
This study's purpose is to use data generated in Renal whole genome and exome Cancer sequencing to target specific areas in multiple other Renal Cancer samples. These areas will then be subjected to bespoke pull downs, tagged and then pool the resultant amplicons. These amplicons will then be sequenced. This is hoped to show the prevalence of previous findings in multiple individuals in a high throughput method.
Study
EGAS00001000095
Non_Tumour_Renal_Cell_Line_Sequencing
Genomic libraries (500 bps) will be generated from total genomic DNA derived from commomon epithelial cancer samples and subjected to total of eight lanes of 37 bp, paired end sequencing on the llumina GA. Paired reads will be mapped to build 37 of the human reference genome to facilitate the generation of genome wide copy number information, and the identification of novel rearranged cancer genes and gene fusions.
Study
EGAS00001000205
ANGIOPREDICT - an FP7-funded project enabling personalised medicine for patients with metastatic colorectal cancer.
In ANGIOPREDICT, academic cancer biologists and industry-based biotechnology researchers will work together with clinicians to identify biomarkers to predict whether individual metastatic colorectal cancer patients will respond positively to Avastin® combination therapy. Diagnostic tests using these biomarkers will also be developed to provide clinicians with the means to predict patient treatment responses in the future.
Study
EGAS00001005423
Expression profiles and genetic makeup of metastases of a cancer of unknown primary.
Study
EGAS00001004059
Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer
Study
EGAS00001004055
NPY methylated ctDNA is a promising biomarker for treatment response monitoring in metastatic colorectal cancer
Study
EGAS00001006820
Low-coverage whole-genome sequencing of cancer and healthy plasma circulating DNA
Study
EGAS00001007593
Genomic profiling of subcutaneous patient derived xenograft models of solid childhood cancer
Study
EGAS00001006710
DEREGULATION OF PRE-mRNA SPLICING IN MISMATCH REPAIR DEFICIENT COLORECTAL CANCER
Study
EGAS00001004863
Genome-wide sequencing of (cell-free) DNA from Nipple aspirate fluid of Breast cancer patients
Study
EGAS00001007214