Single cell Transcriptomic Analysis of Cellular Heterogeneity in Human Colorectal Tumors

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Dataset ID	Description	Technology	Samples
EGAD00001002727	1,591 single cells from 11 colorectal cancer patients were profiled using Fluidigm based single cell RNA-seq protocol to characterized cellular heterogeneity of colorectal cancer. 630 single cells from 7 cell lines were profiled similarly to benchmark de novo cell type identification algorithms.	Illumina HiSeq 3000	2221
EGAD00001007946	57 Bone marrow specimens for 5 healthy bone marrow and 24 CML samples profiled with 10X scRNA-seq 5' upon separation using MACS for CD34.	Illumina HiSeq 2000 Illumina HiSeq 3000 Illumina HiSeq 4000	57

Publications	Citations
Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer. Eum HH, Kwon M, Ryu D, Jo A, Chung W, Kim N, Hong Y, Son DS, Kim ST, Lee J, Lee HO, Park WY. Exp Mol Med 52: 2020 1976-1988	86
Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis. Simó-Riudalbas L, Offner S, Planet E, Duc J, Abrami L, Dind S, Coudray A, Coto-Llerena M, Ercan C, Piscuoglio S, Andersen CL, Bramsen JB, Trono D. Nat Commun 13: 2022 4913	23
Genome-scale modeling predicts metabolic differences between macrophage subtypes in colorectal cancer. Gelbach PE, Finley SD. iScience 26: 2023 107569	12
Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis. Jia B, Shi Y, Hong Y, Yang C, Roycroft D, Kamal S, Mukherjee S, Ueberheide B, Grier A, JRI Live Cell Bank, Witherspoon M, Bilal M, He B, Lacko LA, Lipkin SM, Tejpar S, Blander JM. Nature 652: 2026 1362-1374	1
Single-Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti-PD-1 Resistance in Colorectal Cancer. Kang D, Xie SZ, Luo YZ, Deng XP, Tan XR, Chen ZG, Zeng LX, Chen G, Ding PR, Pan ZZ, Zhang RX. Adv Sci (Weinh) None: 2026 e76143	0