Paraganglioma Smart-Seq2 Single Nuclei Sequencing Data

Paraganglioma is a rare neuroendocrine tumor that originates from chromaffin cells of the adrenal medulla or extra-adrenal paraganglia. This study aims to investigate the heterogeneity of this tumor and to identify potential biomarkers associated with its malignancy. To achieve this, we performed single-nucleus RNA sequencing of human paraganglioma samples using the SMART-Seq2 protocol.

Type: Transcriptome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001689	This dataset comprises single-nucleus transcriptomic profiles from 9 human paraganglioma samples. Nuclei were isolated and processed using the SMART-Seq2 protocol to enable full-length, high-resolution RNA sequencing at the single-nucleus level. cDNA libraries were generated and sequenced on the Illumina HiSeq 2500 platform. The resulting raw sequencing data are provided as .fastq files for downstream analysis.	Illumina HiSeq 2500	9

Publications	Citations
Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas. Bullova P, Cui P, Arceo M, Zhu J, Li W, Plescher M, Poltorachenko V, Stripling K, Santangeli C, Mykhaylechko L, Kastriti ME, Larsson C, Juhlin CC, Mints M, Schlisio S. NPJ Precis Oncol 9: 2025 324	0