Dynamic human admixture histories over the past ~1,300 years at the northern Himalayan frontier

Archaeological and paleogenomic evidence from the Tibetan Plateau and high-altitude Central Himalayas suggest biocultural connections with each other and with lowland East, Central, and South Asia. However, genetic histories at the northern frontier of the Indian Himalayas, which is geographically more proximal to Central and lowland South Asia, remain underexplored. We analyzed genome-wide data from 7 ancient (~2300 to 100 years old) and 10 present-day individuals from the northern Indian Himalayas and one ~3370-year-old individual from the Central Himalayas in Nepal. Ancient and present-day individuals from the northern Himalayas predominantly have Tibetan-related genetic ancestry, likely the source of high-altitude adaptive variants in these individuals, with substantial Steppe-related genetic ancestry that is observed in all individuals dating between ~1300 years and present day. In addition, some present-day individuals have lowland South Asian admixture. Our analyses reveal a dynamic interplay between genetic admixture and continuity in the northern Himalayas.

Type: Whole Genome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001925	Whole-genome sequencing data from ten present-day individuals from Himachal Pradesh, India. DNA from these ten present-day individuals was converted to double-stranded libraries and sequenced on Illumina NovaSeq 6000 in 150 bp paired-end mode. The dataset consists of raw fastq and bam (hg19) files.	Illumina NovaSeq 6000	10

Publications	Citations
Dynamic human admixture histories over the past ~1300 years at the northern Himalayan frontier. Bandyopadhyay E, Witonsky D, de la Fuente Castro C, Pasupuleti N, Urban Aragon JA, Lee J, Shastry V, Sander N, Ahlawat B, Dwivedi A, Angmo T, Sharma A, Kaushik A, Moots HM, Moreno-Mayar JV, Kumar S, Bhatt RC, Mengwal KB, Chauhan H, Ganjoo RK, Mushrif-Tripathy V, Ota SB, Warinner C, Aldenderfer M, Di Rienzo A, Jeong C, Rawat NS, Norbu T, Singh E, Nautiyal V, Raghavan M, Rai N. Sci Adv 11: 2025 eadu9625	0

Publications

Citations

Dynamic human admixture histories over the past ~1300 years at the northern Himalayan frontier.
Bandyopadhyay E, Witonsky D, de la Fuente Castro C, Pasupuleti N, Urban Aragon JA, Lee J, Shastry V, Sander N, Ahlawat B, Dwivedi A, Angmo T, Sharma A, Kaushik A, Moots HM, Moreno-Mayar JV, Kumar S, Bhatt RC, Mengwal KB, Chauhan H, Ganjoo RK, Mushrif-Tripathy V, Ota SB, Warinner C, Aldenderfer M, Di Rienzo A, Jeong C, Rawat NS, Norbu T, Singh E, Nautiyal V, Raghavan M, Rai N. Sci Adv 11: 2025 eadu9625