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FHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28A

ZFHX4 as a transcription factor specifically induced during the in vitro differentiation of iPSC-derived mDANs. Depletion of ZFHX4 during neuronal differentiation led to a significant reduction in the number of mDANs while its overexpression did not lead to any changes in mDAN count. Identification of ZFHX4 target genes using CUT&Tag profiling and RNA-seq upon ZFHX4 knock-down (KD) revealed its involvement in cell cycle regulation during mDAN differentiation

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Data Access Policy 1. The access to the data will be granted by the Data Access Committee (DAC). The DACs will review and approve or disapprove all requests from the research community for data access. Decisions to grant access are made based on whether the request conforms to the specifications within this data access policy. If the DAC decides to grant access, a Data Access Agreement must be signed between the data owner and the user institution. 2. Applications are welcome for studies in all research areas 3. The User Institution agrees to only use these Data for the purpose of the Project and only for Research Purposes. 4. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. 5. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 6. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 7. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 8. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 9. The User Institution agrees to follow the Publication Policy which includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 10. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of of these Data, or conclusion drawn directly from these Data 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000001111 Transcriptome Analysis
EGAS50000001112 Epigenetics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF50000400775 fastq.gz 1.6 GB
EGAF50000400776 fastq.gz 1.6 GB
EGAF50000400777 fastq.gz 1.7 GB
EGAF50000400778 fastq.gz 1.8 GB
EGAF50000400779 fastq.gz 1.6 GB
EGAF50000400780 fastq.gz 1.7 GB
EGAF50000400781 fastq.gz 1.6 GB
EGAF50000400782 fastq.gz 1.6 GB
EGAF50000400783 fastq.gz 1.5 GB
EGAF50000400784 fastq.gz 1.5 GB
EGAF50000400785 fastq.gz 1.7 GB
EGAF50000400786 fastq.gz 1.7 GB
EGAF50000400787 fastq.gz 704.8 MB
EGAF50000400788 fastq.gz 680.9 MB
EGAF50000400789 fastq.gz 1.1 GB
EGAF50000400790 fastq.gz 1.1 GB
16 Files (23.2 GB)