Search Results - EGA European Genome-Phenome Archive

Genome sequence data from a metastatic squamous cell carcinoma of the oropharynx patient

Genome sequence data from a metastatic squamous cell carcinoma of the oropharynx patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001003691

Genome and transcriptome sequence data from a metastatic gastrointestinal stromal tumour patient

Genome and transcriptome sequence data from a metastatic gastrointestinal stromal tumour patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001003692

Genome and transcriptome sequence data from a metastatic pancreatic neck adenocarcinoma patient

Genome and transcriptome sequence data from a metastatic pancreatic neck adenocarcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004666

Genome and transcriptome sequence data from a metastatic uveal melanoma patient

Genome and transcriptome sequence data from a metastatic uveal melanoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004667

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the esophagus patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the esophagus patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004668

Genome and transcriptome sequence data from a non-small cell lung carcinoma patient

Genome and transcriptome sequence data from a non-small cell lung carcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004669

Genome and transcriptome sequence data from a metastatic spindle cell sarcoma patient

Genome and transcriptome sequence data from a metastatic spindle cell sarcoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004670

Genome and transcriptome sequence data from a metastatic breast carcinoma patient

Genome and transcriptome sequence data from a metastatic breast carcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004671

Genome and transcriptome sequence data from a metastatic rectal adenocarcinoma patient

Genome and transcriptome sequence data from a metastatic rectal adenocarcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004685

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the GE junction patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the GE junction patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004684

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the lung patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the lung patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004680

Genome and transcriptome sequence data from a metastatic thymic carcinoma patient

Genome and transcriptome sequence data from a metastatic thymic carcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004678

Genome and transcriptome sequence data from a metastatic colon adenocarcinoma patient

Genome and transcriptome sequence data from a metastatic colon adenocarcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004677

Genome and transcriptome sequence data from a metastatic breast carcinoma patient

Genome and transcriptome sequence data from a metastatic breast carcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004676

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the lung patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the lung patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004673

Genome and transcriptome sequence data from a extramedullary spinal ependymoma patient

Genome and transcriptome sequence data from a extramedullary spinal ependymoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004635

Genome and transcriptome sequence data from a metastatic endometrioid/mucinous ovarian carcinoma patient

Genome and transcriptome sequence data from a metastatic endometrioid/mucinous ovarian carcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004636

Genome and transcriptome sequence data from a metastatic clear cell carcinoma of gynecological origin patient

Genome and transcriptome sequence data from a metastatic clear cell carcinoma of gynecological origin patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004637

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the pancreas patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the pancreas patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004640

Genome and transcriptome sequence data from a metastatic alveolar soft part sarcoma patient

Genome and transcriptome sequence data from a metastatic alveolar soft part sarcoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004641

Genome and transcriptome sequence data from a metastatic lung adenocarcinoma patient

Genome and transcriptome sequence data from a metastatic lung adenocarcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004644

Genome and transcriptome sequence data from a metastatic uveal melanoma patient

Genome and transcriptome sequence data from a metastatic uveal melanoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004647

Genome and transcriptome sequence data from a high grade sarcoma of the epithelioid/spindle cell patient

Genome and transcriptome sequence data from a high grade sarcoma of the epithelioid/spindle cell patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004648

Genome and transcriptome sequence data from a metastatic breast carcinoma patient

Genome and transcriptome sequence data from a metastatic breast carcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004651

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the stomach patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the stomach patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004652

Genome and transcriptome sequence data from a breast invasive ductal carcinoma patient

Genome and transcriptome sequence data from a breast invasive ductal carcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004654

Genome and transcriptome sequence data from a locally advanced oropharyngeal carcinoma patient

Genome and transcriptome sequence data from a locally advanced oropharyngeal carcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004655

Genome and transcriptome sequence data from a metastatic ampullar carcinoma patient

Genome and transcriptome sequence data from a metastatic ampullar carcinoma patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004657

Genome and transcriptome sequence data from a metastatic primitive neuro-ectodermal tumor of the testicle patient

Genome and transcriptome sequence data from a metastatic primitive neuro-ectodermal tumor of the testicle patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004660

Genome and transcriptome sequence data from a metastatic clear cell carcinoma of the ovary patient

Genome and transcriptome sequence data from a metastatic clear cell carcinoma of the ovary patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004661

Genome and transcriptome sequence data from a metastatic leiomyosarcoma of pancreas patient

Genome and transcriptome sequence data from a metastatic leiomyosarcoma of pancreas patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004662

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the pancreas patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the pancreas patient, generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

Dataset EGAD00001004663

Distinct evolutionary trajectories of primary high grade serous ovarian cancers revealed through spatial mutational proﬁling

High-grade serous ovarian cancer (HGSC) is characterized by poor outcome, often attributed to the emergence of treatment-resistant subclones. We sought to measure the degree of genomic diversity within primary, untreated HGSCs to examine the natural state of tumour evolution prior to therapy. We performed exome sequencing, copy number analysis, targeted amplicon deep sequencing and gene expression profiling on 31 spatially and temporally separated HGSC tumour specimens (six patients), including ovarian masses, distant metastases and fallopian tube lesions. We found widespread intratumoural variation in mutation, copy number and gene expression profiles, with key driver alterations in genes present in only a subset of samples (eg PIK3CA, CTNNB1, NF1). On average, only 51.5% of mutations were present in every sample of a given case (range 10.2 to 91.4%), with TP53 as the only somatic mutation consistently present in all samples. Complex segmental aneuploidies, such as whole-genome doubling, were present in a subset of samples from the same individual, with divergent copy number changes segregating independently of point mutation acquisition. Reconstruction of evolutionary histories showed one patient with mixed HGSC and endometrioid histology, with common aetiologic origin in the fallopian tube and subsequent selection of different driver mutations in the histologically distinct samples. In this patient, we observed mixed cell populations in the early fallopian tube lesion, indicating that diversity arises at early stages of tumourigenesis. Our results revealed that HGSCs exhibit highly individual evolutionary trajectories and diverse genomic tapestries prior to therapy, exposing an essential biological characteristic to inform future design of personalized therapeutic solutions and investigation of drug-resistance mechanisms

Dataset EGAD00001000669

Distinct evolutionary trajectories of primary high grade serous ovarian cancers revealed through spatial mutational profiling

High-grade serous ovarian cancer (HGSC) is characterized by poor outcome, often attributed to emergence of treatment-resistant sub-clones. We sought to measure the degree of genomic diversity within primary, untreated HGSC to examine the natural state of tumor evolution prior to therapy. We performed exome sequencing, copy number analysis, targeted amplicon deep sequencing and gene expression profiling on thirty-one spatially and temporally separated HGSC tumor specimens (six patients) including ovarian masses, distant metastases, and fallopian tube lesions. We found widespread intra-tumoral variation in mutation, copy number, and gene expression profiles, with key driver alterations in genes present in only a subset of samples (e.g. PIK3CA, CTNNB1, NF1). On average, only 51.5% of mutations were present in every sample of a given case (range: 10.2% to 91.4%), with TP53 as the only somatic mutation consistently present in all samples. Complex segmental aneuploidies, such as whole genome doubling, were present in a subset of samples from the same individual, with divergent copy number changes segregating independently of point mutation acquisition. Reconstruction of evolutionary histories showed one patient with mixed HGSC and endometrioid histology with common etiologic origin in the fallopian tube and subsequent selection of different driver mutations in the histologically distinct samples. In this patient, we observed mixed cell populations in the early fallopian tube lesion, indicating diversity arises at early stages of tumorigenesis. Our results reveal that HGSC exhibit highly individual evolutionary trajectories and diverse genomic tapestries prior to therapy, exposing an essential biological characteristic to inform future design of personalized therapeutic solutions and investigation of drug resistance mechanisms.

Dataset EGAD00001000974

12221 results for "cancer rna-seq"

in 48.52 milliseconds.

Genome sequence data from a metastatic squamous cell carcinoma of the oropharynx patient

Genome and transcriptome sequence data from a metastatic gastrointestinal stromal tumour patient

Genome and transcriptome sequence data from a metastatic pancreatic neck adenocarcinoma patient

Genome and transcriptome sequence data from a metastatic uveal melanoma patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the esophagus patient

Genome and transcriptome sequence data from a non-small cell lung carcinoma patient

Genome and transcriptome sequence data from a metastatic spindle cell sarcoma patient

Genome and transcriptome sequence data from a metastatic breast carcinoma patient

Genome and transcriptome sequence data from a metastatic rectal adenocarcinoma patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the GE junction patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the lung patient

Genome and transcriptome sequence data from a metastatic thymic carcinoma patient

Genome and transcriptome sequence data from a metastatic colon adenocarcinoma patient

Genome and transcriptome sequence data from a metastatic breast carcinoma patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the lung patient

Genome and transcriptome sequence data from a extramedullary spinal ependymoma patient

Genome and transcriptome sequence data from a metastatic endometrioid/mucinous ovarian carcinoma patient

Genome and transcriptome sequence data from a metastatic clear cell carcinoma of gynecological origin patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the pancreas patient

Genome and transcriptome sequence data from a metastatic alveolar soft part sarcoma patient

Genome and transcriptome sequence data from a metastatic lung adenocarcinoma patient

Genome and transcriptome sequence data from a metastatic uveal melanoma patient

Genome and transcriptome sequence data from a high grade sarcoma of the epithelioid/spindle cell patient

Genome and transcriptome sequence data from a metastatic breast carcinoma patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the stomach patient

Genome and transcriptome sequence data from a breast invasive ductal carcinoma patient

Genome and transcriptome sequence data from a locally advanced oropharyngeal carcinoma patient

Genome and transcriptome sequence data from a metastatic ampullar carcinoma patient

Genome and transcriptome sequence data from a metastatic primitive neuro-ectodermal tumor of the testicle patient

Genome and transcriptome sequence data from a metastatic clear cell carcinoma of the ovary patient

Genome and transcriptome sequence data from a metastatic leiomyosarcoma of pancreas patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the pancreas patient

Distinct evolutionary trajectories of primary high grade serous ovarian cancers revealed through spatial mutational proﬁling

Distinct evolutionary trajectories of primary high grade serous ovarian cancers revealed through spatial mutational profiling

Genome and transcriptome sequence data from a metastatic breast carcinoma patient

Genome and transcriptome sequence data from a squamous cell carcinoma of vulva patient

Genome and transcriptome sequence data from a vulvar metastatic melanoma patient

Genome and transcriptome sequence data from a squamous cell carcinoma of anal canal patient

Genome and transcriptome sequence data from a right breast carcinoma patient

Genome and transcriptome sequence data from a carcinoma of left lower outer quadrant patient

Genome and transcriptome sequence data from a ductal carcinoma of left breast patient

Genome and transcriptome sequence data from an infiltrating ductal carcinoma of right breast patient

Genome and transcriptome sequence data from an adenocarcinoma of lung patient

Genome and transcriptome sequence data from a metastatic neuroendocrine carcinoma patient

Genome and transcriptome sequence data from an adnexal tumor probable of Wolffian origin patient

Genome and transcriptome sequence data from an adenomacarcinoma of vulva patient

Genome and transcriptome sequence data from a neuroendocrine tumor likely pancreatic origin patient

Genome and transcriptome sequence data from a metastatic adenocarcinoma of the GE junction patient

Genome and transcriptome sequence data from a pancreatic ductal adenocarcinoma patient

Genome and transcriptome sequence data from a medullary thyroid carcinoma patient